Integration of microarray analysis into the clinical diagnosis of hematological malignancies: How much can we improve cytogenetic testing?

Integration of microarray analysis into the clinical diagnosis of hematological malignancies: How much can we improve cytogenetic testing?

PURPOSE To evaluate the clinical utility, diagnostic yield and rationale of integrating microarray analysis in the clinical diagnosis of hematological malignancies in comparison with classical chromosome karyotyping/fluorescence in situ hybridization (FISH). METHODS G-banded chromosome analysis, FISH and microarray studies using customized CGH and CGH+SNP designs were performed on 27 samples ...

How Much Can We Save the Cost from Shifting from Single - Test Strip to Multiple - Test Strip in Point of Care Testing Analysis for Common Clinical Chemistry Parameters ?

Semantic Integration in Multidatabase Systems: How Much Can We Integrate?

This chapter reviews briefly the semantic integration issues in multidatabase development and provides a standardized representation for classifying semantic conflicts. We begin by summarizing the methods and issues in multidatabase design. From the perspective of database integration, we identify that semantic conflict is the main issue. We explore the idea further by examining semantic confli...

Molecular cytogenetic aspects of hematological malignancies: clinical implications.

The field of molecular cytogenetics has had a great impact on many aspects of medical and basic sciences. During the past 30 years, the application of molecular cytogenetic methodologies has resulted in remarkable advances in the field of cancer genetics and cytogenetics. These advances have led to the establishment of chromosome patterns as diagnostic and prognostic indexes in an array of acut...

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